More information in the GO evidence code guide
,Inferred from Biological aspect of Ancestor
Manual assertion according to rulesi, jPOST - Japan Proteome Standard Repository/Database, MassIVE - Mass Spectrometry Interactive Virtual Environment, PaxDb, a database of protein abundance averages across all three domains of life, ProteomicsDB: a multi-organism proteome resource, GlyGen: Computational and Informatics Resources for Glycoscience, iPTMnet integrated resource for PTMs in systems biology context. SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, Protein Data Bank in Europe - Knowledge Base, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Identification of Orthologs from Complete Genome Data, Database for complete collections of gene phylogenies, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Simple Modular Architecture Research Tool; a protein domain database, PROSITE; a protein domain and family database. The alpha-2 (α 2) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the G i heterotrimeric G-protein. Organism.Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. The version number for both the entry and the canonical sequence are also displayed.
This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, negative regulation of epinephrine secretion, negative regulation of norepinephrine secretion, negative regulation of uterine smooth muscle contraction, positive regulation of neuron differentiation, integral component of postsynaptic membrane, Proc. It is useful for tracking sequence updates. Function i. Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. These are stable identifiers and should be used to cite UniProtKB entries. Organism. Natl. Alpha-2C adrenergic receptor. Some species other than humans express a fourth α2D-adrenergic receptor as well. HTR2C denotes the human gene encoding for the receptor, that in humans is located at the X chromosome. RNAct, Protein-RNA interaction predictions for model organisms. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max), Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, SignaLink: a signaling pathway resource with multi-layered regulatory networks, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform, The Pharmacogenetics and Pharmacogenomics Knowledge Base, Pharos NIH Druggable Genome Knowledgebase, ChEMBL database of bioactive drug-like small molecules, BioMuta curated single-nucleotide variation and disease association database, Domain mapping of disease mutations (DMDM),Manual validated information which has been generated by the UniProtKB automatic annotation system.
have the same checksum value, the likelihood that this would happen These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. ,When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.
,This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.
It should be noted that while, in theory, two different sequences could Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.
,This section provides any useful information about the protein, mostly biological knowledge.
.Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).
of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
,This subsection of the 'Subcellular location' section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.
,This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. Reviewed-Annotation score: -Experimental evidence at transcript level i.
More information in the GO evidence code guide
, Inferred from biological aspect of ancestor,Traceable Author Statement
The alpha(2C)-adrenergic receptor mediates hyperactivity of coloboma mice, a model of attention deficit hyperactivity disorder. is extremely low. Protein Ontology Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content., Implicated in catechol agonist binding and receptor activation,The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,Inferred from Physical Interaction
Acad. of multiple genes (paralogs). from the sequence.However UniProtKB may contain entries with identical sequences in case