Therefore, close monitoring is warranted when drugs metabolized by these enzymes are given concomitantly with milk thistle.Asher 2017, Milić 2013, Polachi 2016, Sprouse 2016, Antiretrovirals: Milk thistle may reduce the efficacy of protease inhibitors, integrase inhibitors, and non-nucleoside reverse transcriptase inhibitors. Caution and close monitoring is warranted if using these agents concomitantly with milk thistle.Jalloh 2017, CYP2C9 Substrates: Milk thistle may decrease concentrations of medications that are metabolized by CYP2C9, such as warfarin, phenytoin, and diazepam. Milk thistle thrives in dry and rocky soils, but has a preference for sunny or lightly shaded areas. It is also worth noting that milk thistle has been shown to inhibit fat cells in lab cultures; however, these results are still widely inconclusive. Copyright © Ayurvedaforall .in 2016. This is a hepatic tonic and also supplies digestive support. anti-inflammatory properties of milk thistle, The National Center for Complementary and Integrative Health, The Mayo Clinic notes the following potential interactions. A clinical trial has been underway for more than ten years studying milk thistle and Amanita phalloides ingestion. Usage Frequency: 1 Subacute toxicity studies suggest no toxicity in rats and monkeys at dosages up to 2 g/kg for 13 weeks, and up to 1 g/kg in rats and dogs for up to 26 weeks. The flowers are reddish-purple and ridged with sharp spines. The National Center for Complementary and Integrative Health notes the following about milk thistle side effects: Milk thistle is well-tolerated in clinical trials, but on occasion people report gastrointestinal side effects. We're part of Translated, so if you ever need professional translation services, then go checkout our main site, Usage Frequency: 1, Usage Frequency: 2, Usage Frequency: 60, Usage Frequency: 3, Usage Frequency: 6. Pliny the Elder (AD 23 to 79) noted that the plant's juice was excellent for "carrying off bile." Like most herbal supplements, the long-term impact has not been studied with regards to milk thistle; however, it is considered to be a safe herb for supplementation. At the end of the first to sixth week, median World Health Organization and National Cancer Institute Common Terminology Criteria scores were significantly reduced in the patients treated with silymarin (P<0.05). Reference: Translated.com, Last Update: 2014-11-21 The Mayo Clinic notes the following potential interactions that you may experience while taking milk thistle with other medications or substances: Cytochrome P450 2C9 (CYP2C9) substrates, including valium and warfarin (and the same drugs under different names). Milk thistle es una planta que también se conoce como Artichaut Sauvage, Cardo Lechoso, Cardui Mariae, Carduus marianus, Chardon Argenté, Chardon de Marie, Épine Blanche, Holy Thistle, Lady's Thistle, Lait de Notre-Dame, Legalon, Marian Thistle, Mariendistel, Mary Thistle, Shui Fei Ji, Silibinin, Silybe de Marie, Silybum, Silymarin, y otros nombres. No le dé ningún suplemento herbal de la salud a un niño sin el consejo médico. Usage Frequency: 1 Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Milk thistle has demonstrated efficacy in liver damage associated with acetaminophen, arsenic, and carbon tetrachloride.Neha 2016, In a study of rats, silibinin mitigated the increases in liver function measures caused by combination therapy with isoniazid and zidovudine.Ramanathan 2017, Prevention of anti-tuberculosis (TB) drug–induced liver injury was assessed in a double-blind, randomized, placebo-controlled trial in patients with newly diagnosed pulmonary tuberculosis (N=55) who planned to receive standard therapy with isoniazid, rifampicin, pyrazinamide, and ethambutol.