Finally, M. Li et al. As an interdisciplinary field of science, bioinformatics combines biology, computer science, information engineering, mathematics and statistics to analyze and interpret the biological data. One key area of bioinformatics is in the area of drug discovery and the areas of bioinformatics needed in drug discovery are molecular docking, molecular dynamics and simulations, free energy calculations and network pharmacology. For complex diseases, such as cancers, the driver genes are usually a cluster of genes in a regulatory network. Y. Fang et al. Review articles are excluded from this waiver policy. It is also efficient in saving time and energy. H.-B. Which country is best, in general, for postdoc and why? X. Wu et al. In our field of research (chemistry), successful PhD research often requires a lot of experimental work in the laboratory. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. "Bioinformatics: Applications and Implications." I do not mean mistakes or contaminations that can exist because of carelessness in the past that was not caught. machine learning-based bioinformatics has been very useful in precision medicine. It is, therefore, important that the field of Bioinformatics is advanced to help solve the current problem limiting research in life sciences. Bioinformatics has been used for in silico analyses of biological queries using mathematical and statistical techniques. B. Xie et al. SRMDAP could also predict diseases without any related miRNAs and miRNAs without any related diseases. We are grateful to the authors for contributing their valuable work to this special issue and the reviewers for this constructive comments. The hyper cluster COVID19 (SARS-CoV/2: Betacoronavirus: Sarb... 2019nCoV or SARS-CoV/2 Coronavirus {Riboviria Nidovirales Co... https://www.researchgate.net/publication/339781431, https://www.researchgate.net/figure/ResGa-FxFac-post_fig95_339781431, https://www.researchgate.net/figure/ResGa-FxFac-post_fig52_339781431, https://www.researchgate.net/figure/ResGa-FxFac-post_fig50_339781431, https://www.researchgate.net/figure/ResGa-FxFac-post_fig51_339781431, GitHub Statistics as a Measure of the Impact of Open-Source Bioinformatics Software, The vervet regulator of G protein signaling 4 (RGS4) gene, a candidate gene for quantifiable behavioral dimensions associated with psychopathology : sequence, bioinformatic analysis, and association study of a novel polymorphism with social isolation, Bioinformatics Analysis of α-Amylase Three-Dimensional Structure in Aspergillus oryzae. Ideally, it should provide a good general introduction to the subject - probably aimed at BSc/MSc level students - and be clearly written with informative illustrations. All rights reserved. Many bioinformatics tools developed for DNA microarrays can be reused in proteomics, however, the uniquely quantitative nature of proteomics data also offers the novel analysis possibilities, which directly enhance the biological mechanisms (Kumar & Mann, 2009). © 2008-2020 ResearchGate GmbH. Bioinformatics, as a subdiscipline of biology and computer science, is concerned with the acquisition, storage, analysis, and dissemination of biological data, most often DNA and amino acid sequences. (2011) stated that protein interaction databases play an increasingly important role in systems biology approaches to the study of disease. Bioinformatics involves algorithms to represent, store, and analyze the biological data (Li, 2015), including DNA (deoxyribosenucleic acid) sequence, RNA (ribosenucleic acid) expression, protein, and small-molecule abundance within cells (Altman, 2012). Journal's impact fac... Regulators of G-protein coupled signaling (RGS) accelerate GTP hydrolysis and consequently influence signal termination. In your opinion, what is the most positive aspect of this pandemic? Thanks! Some authors are using a series of new alternative of ionic liquids, named DES and Ch-DES and claimed to overcome the disadvantages of conventional extraction methods. Application of bioinformatics in which preventive medicine or preventive care are taken to prevent diseases, rather than curing them or treating their symptoms. ), Kasemsap, Kijpokin. In your opinion, what is the most positive aspect of this pandemic? Bioinformatics is an indispensable tool in the field of research with the current large amount of genomic data generated continually. To Support Customers in Easily and Affordably Obtaining the Latest Peer-Reviewed Research, Copyright © 1988-2020, IGI Global - All Rights Reserved, Additionally, Enjoy an Additional 5% Pre-Publication Discount on all Forthcoming Reference Books, Kasemsap, Kijpokin. Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small group or even individual patients based on their genetics, environment and lifestyle. Metabolomics technology and bioinformatics for precision medicine. Protein-protein interactions have been at the focus of computational biology in recent years (Hooda & Kim, 2012). The AUC of 0.8838 based on leave-one-out cross validation and case studies suggested the excellent performance of the SRMDAP in predicting miRNA-disease associations. not more than five years old). It is useful in genomics to characterize and quantify genes, and also in Proteomics, Transcriptomics, Drug Discovery as well as Personalized Medicine. Ibn Sina National College for Medical Studies. In this special issue, we have received 32 papers, out of which 19 has been accepted for publication. Recently, the interests in proteomics have been increased, and the proteomic methods have been widely applied to many problems in cell biology (Haga & Wu, 2014). Precision medicine relies heavily on developments in systems biology and omics disciplines, including metabolomics. How these solvents overcome it? The results by gene expression data of breast cancer show that the method proposes an effective way to identify reliable disease-associated pathways. To promote the translation of precision medicine from bench to beside and from application of genetic testing to personalized medicine, new analysis methods for NGS and genetic data need to be developed. Recently, potential targets in cancers were identified from gene expression profiles. What's the duration of a PhD in your area? Do you know any masterpieces of art which are devoted to anti-war themes? In, Advances in Bioinformatics and Biomedical Engineering, InfoSci-Computer Science and Information Technology, InfoSci-Medical, Healthcare, and Life Sciences, InfoSci-Education Knowledge Solutions – Books, InfoSci-Social Sciences Knowledge Solutions – Books, InfoSci-Computer Science and IT Knowledge Solutions – Books, Applying Big Data Analytics in Bioinformatics and Medicine. Courcelles et al. How long does a PhD take in your field of research? detected RAS mutation, immunoscore, and PD-L1 expression in 60 Chinese metastatic colorectal cancer (mCRC) patients and suggested PD-L1 expression and RAS status to be prognostic indicators for mCRC patients with palliative operation.