Further information and updates on risk management actions for substances managed under the CMP can be found in the. }xp��v� ��M���'�{���z��|����:_��1f��!���a�Ο�= 2 1 0 obj Brilliant Blue FCF has been previously evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1970 and the EU Scientific Committee for Food (SCF) in 1975. This included reviews through the, Basic Violet 3 has been classified as a substance suspected of causing cancer, according to the. Basic Violet 3, Basic Violet 4, and Basic Blue 7 are also associated with health effects of concern; however, the risk to human health is low, at levels of exposure considered in the assessment. 4 0 obj Individuals with allergic conditions, including dermatitis, suffered an exacerbation of their symptoms following oral exposure. Once in the blood, it may inhibit mitochondrial respiration. You will not receive a reply. Z Yellow No. An amendment to include these 4 substances in the. The stock solution prepared was 1 gram of food colour per 100ml water. Long-term feeding studies in rats and mice, and dermal studies in mice, have failed to generate any convincing evidence of carcinogenicity. SAFETY DATA SHEET Creation Date 03-May-2012 Revision Date 01-Apr-2020 Revision Number 4 1. 5 is an unqualified human health hazard. Brilliant Blue FCF. /Producer(Sub Systems, Inc.)/CreationDate(D:20200401110241+04'00')/ModDate(D:20200401110241+04'00')/Creator(Sub Systems, Inc.) 8 <> E The screening assessment focused on potential risks from exposure of the general population of Canada, rather than occupational exposure. A low acute oral toxicity was indicated in rats. for a period of 13 weeks followed by gross and histopathology examinations. 0.5 Day, C.I. Brilliant Blue FCF was irritating to the skin of humans and to the eyes of rabbits. Details can be found in the proposed risk management approach, including where to send information during the public comment period, ending December 16, 2020. << All of these substances may be released to the Canadian environment as a result of their uses in Canada, including paper dyeing, de-inking of paper, as well as from the formulation, manufacture and consumer use of products containing these substances. FD&C Yellow No. Ames bacterial tests have, in general, given no evidence of mutagenicity. 1907/2006 as amended by (EC) No. As a result of the screening assessment, the Government concluded that Malachite Green may be harmful to human health at levels of exposure considered in the assessment. ����] ���N�?;^k������qqU�͟�ƝoC:~���?�]����O�y�O�����P���T��P6�y�=��%T��ԡ�N�y5�P�P���0��%}�I? In the United States, of the two approved blue dyes (the other being Indigo carmine, or FD&C Blue #2), Brilliant Blue FCF is the more common of the two. Brilliant Blue FCF may also cause effects in aquatic organisms at relatively high concentrations, according to experimental data. 1 Hazards related to chemicals used in the workplace are defined within the. S >> Among natural food additives, food colors like annatto pose quite a few health risks for those who are allergic to it. For manufacturing, processing, laboratory or repacking use only Uses advised against: Uses other than those recommended. Rietjens, I. Stankovic, P. Tobback, T. Verguieva, R.A. Woutersen, Panel on Food Additives and Nutrient Sources Added to Food. 6 The Panel concluded that at Tier 2 the intake estimates are below the ADI at the mean for both adults and children and at the higher level for adults, but above the ADI at the higher level (95 th percentile) for children. %PDF-1.5 3 My understanding is that this basically means that a cell’s ability to convert food to energy may be affected. F There were some limitations to the health effects data available for Malachite Green; therefore, a comparative approach using similar chemicals, called read-across, was used for assessing potential health effects. Health Canada has provided general information on. Carcinogenicity (potential to cause cancer) was the critical effect for characterizing the risk to human health from Basic Violet 4 and Basic Blue 7, using a read-across approach for these 2 substances. Also, Basic Violet 3, Malachite Green, Basic Violet 4, and Basic Blue 7 meet the persistence criteria, but not the bioaccumulation criteria as set out in the, The Government intends to add Basic Violet 3, Malachite Green, Basic Violet 4, and Basic Blue 7 to Schedule 1 of CEPA 1999, also called the. Terms & Conditions